27th tRNA conference - Sciencesconf.org

Sun. 23

Mon. 24

Tue. 25

Wed. 26

Thu. 27

09:00

10:00

11:00

12:00

13:00

14:00

15:00

16:00

17:00

18:00

19:00

20:00

21:00

22:00

Registration
Welcome cocktail

14:00 - 17:30 (3h30)

Registration

16:30 - 17:30 (1h)

Welcome cocktail

Congress opening

17:30 - 18:00 (30min)

Congress opening

Philippe Giegé and Laurence Drouard, Catherine Florentz (University of Strasbourg), Francesco Bonomi (IUBMB), Nicolas Matt (City of Strasbourg, IMCBio)

Keynote Lecture 1 - tRNA semiotics, fragmented ciphers and modern palimpsests

18:00 - 18:30 (30min)

Keynote Lecture 1 - tRNA semiotics, fragmented ciphers and modern palimpsests

Juan Alfonzo

https://trna2018.sciencesconf.org/data/program/Alfonzo_tRNA_abstract.pdf

Keynote Lecture 2 - A Cytoplasmic tRNA Synthetase Splice Variant Promotes Mitochondrial Homeostasis

18:30 - 19:00 (30min)

Keynote Lecture 2 - A Cytoplasmic tRNA Synthetase Splice Variant Promotes Mitochondrial Homeostasis

Paul Schimmel

https://trna2018.sciencesconf.org/data/program/Schimmel_tRNA_abstract.pdf

Diner

19:00 - 21:30 (2h30)

Diner

tRNA biogenesis in evolution

9:00 - 10:35 (1h35)

tRNA biogenesis in evolution

Juan Alfonzo and Mario Mörl

› tRNA Travels Within Eukaryotic Cells - Anita Hopper 09:00-09:25 (25min)

› tRNA decay quality control pathways in yeast - Eric Phizicky 09:25-09:50 (25min)

› tRNA biogenesis pathway in human cells - Yasutoshi Akiyama 09:50-10:05 (15min)

› Processing of armless mitochondrial tRNAs in Romanomermis culicivorax – How CCA-adding enzymes recognize unusual tRNA structures - Oliver Hennig 10:05-10:20 (15min)

› Hierarchical groove discrimination by Class I and II aminoacyl-tRNA synthetases reveals a palimpsest of the operational RNA code in the tRNA acceptor-stem bases - Charles Carter 10:20-10:35 (15min)

Coffee break

10:40 - 11:00 (20min)

Coffee break

tRNA biogenesis in evolution

11:00 - 12:30 (1h30)

tRNA biogenesis in evolution

Sidney Altman endowment session

› tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes - André Schneider 11:00-11:30 (30min)

› Structural basis of tRNA aminoacylation-dependent transcription attenuation by a T-box riboswitch - Jinwei Zhang 11:30-12:00 (30min)

› Studies on bacteria that encode two types of RNase P, the classical RNA-based and a novel RNA-free RNase P - Roland K. Hartmann 12:00-12:15 (15min)

› Roles and interplay of the subunits of human mitochondrial RNase P - Walter Rossmanith 12:15-12:30 (15min)

Three flash talks

12:30 - 12:40 (10min)

Three flash talks

Shikha Shikha - Eleni Kaliatsi - Isabell Schencking

Lunch

12:40 - 14:00 (1h20)

Lunch

tRNA modifications

14:00 - 15:50 (1h50)

tRNA modifications

Henri Grosjean and Valérie de Crécy-Lagard

› Comparative genomic analysis of queuine salvage in bacteria leads to the discovery of novel enzymes - Valerie de Crecy-Lagard 14:00-14:25 (25min)

› tRNA modifications and cellular quality control - Sebastian Leidel 14:25-14:50 (25min)

› The noncanonical lysine acetyltransferase activity of Elongator complex subunit 3 - Ting-Yu Lin 14:50-15:05 (15min)

› t6A modification of A37 position in tRNA and its role in plant development - Elena Zemlyanskaya 15:05-15:20 (15min)

› Structure of yeast tRNA Nm34 methyltransferase Trm7-Trm734 complex reveals its novel bipartite interaction essential for 2´-O-methylation of N34 in the wobble position of three specific tRNA species - Akira Hirata 15:20-15:35 (15min)

› Structural characterisation of bacterial m1A22 tRNA methyltransferase TrmK: Insights into tRNA recognition - Carine Tisné 15:35-15:50 (15min)

Three flash talks

15:50 - 16:00 (10min)

Three flash talks

Rościsław Krutyhołowa - Francesca Tuorto - Laura Antoine

Coffee break

16:00 - 16:30 (30min)

Coffee break

tRNA modifications

16:30 - 18:20 (1h50)

tRNA modifications

Henri Grosjean and Valérie de Crécy-Lagard

› Dynamic regulation of tRNA modification under physiological and pathological conditions - Tsutomu Suzuki 16:30-16:55 (25min)

› Diversity of I34 tRNAs in extant species, and their impact on proteome composition - Lluís Ribas de Pouplana 16:55-17:20 (25min)

› Structure and Mechanism of Threonylcarbamoyl Adenosine Biosynthesis in Bacteria - Naduni Paranagama - Manal Swairjo 17:20-17:35 (15min)

› CRYSTAL STRUCTURES OF [4Fe-4S]-DEPENDENT tRNA THIOLASES REVEAL A NEW MECHANISM OF tRNA THIOLATION - Béatrice Golinelli-Pimpaneau 17:35-17:50 (15min)

› TrmA plays an important role during early tRNA maturation by methylating and folding all tRNAs - Ute Kothe 17:50-18:05 (15min)

› Structural and biochemical analysis of the dual-specificity Trm10 enzyme from Thermococcus kodakaraensis prompts reconsideration of its catalytic mechanism. - Ranjan Kumar Singh 18:05-18:20 (15min)

Four flash talks

18:20 - 18:35 (15min)

Four flash talks

Eva Hegedüsová - Sophia Missoury - Mari Tagel - Qinghai Zhang

Diner

19:00 - 20:30 (1h30)

Diner

Poster session 1

20:30 - 21:30 (1h)

Poster session 1

https://trna2018.sciencesconf.org/data/program/Poster_Abstracts_tRNA_2021.pdf

tRNA in translation

9:00 - 10:40 (1h40)

tRNA in translation

Yaser Hashem and Joseph Puglisi

› Dynamic role of tRNA in biology - Joseph Puglisi 09:00-09:25 (25min)

› Protein synthesis: from ribosome assembly to targeting of membrane proteins - Nenad Ban 09:25-09:50 (25min)

› Logical engineering of D-arm and T-stem of tRNA for incorporation of non-proteinogenic amino acids - Takayuki Katoh 09:50-10:05 (15min)

› Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 and E-tRNA - Bertrand Beckert 10:05-10:20 (15min)

› Unique composition and architecture of Arabidopsis thaliana mitochondrial ribosome - Florent Waltz 10:20-10:35 (15min)

Two flash talks
tRNA in translation

10:35 - 10:40 (05min)

Two flash talks

Sylvain Debard - Jessica Hobson

Coffee break

10:40 - 11:00 (20min)

Coffee break

tRNA in translation

11:00 - 12:40 (1h40)

tRNA in translation

Yaser Hashem and Joseph Puglisi

› Human mitoribosomes: their idiosyncrasies and behaviour - Zofia Chrzanowska-Lightowlers 11:00-11:25 (25min)

› A cellular Quisling factor: antibacterial RNase toxins collaborate with elongation factor Tu to cleave specific tRNA isoacceptors - Christopher Hayes 11:25-11:50 (25min)

› tRNA accommodation during archaeal translation initiation - Yves Mechulam 11:50-12:05 (15min)

› Concerted regulation of mitochondrial and nuclear tRNA processing - Aleksandra Filipovska 12:05-12:20 (15min)

› Cellular levels of readthrough inducing tRNAs and their consequences in yeast and mammals. - Petra Beznoskova 12:20-11:35 (-1h-45)

Two flash talks
tRNA in translation

12:35 - 12:40 (05min)

Two flash talks

Lorenzo Leiva - Mariia Rybak

Lunch

12:40 - 14:00 (1h20)

Lunch

tRNA in translation

14:00 - 14:55 (55min)

tRNA in translation

Yaser Hashem and Joseph Puglisi

› Polymorphic mutations linked to tRNA and changes of local speed of mRNA translation - Zoya Ignatova 14:00-14:25 (25min)

› tRNA-recognition mechanism of Sec-synthetic enzymes - Miljan Simonovic 14:25-14:40 (15min)

› Reading the ribosome: monitoring translation in living cells with FRET-labeled tRNAs - Wissam Mansour 14:40-14:55 (15min)

tRNAomics and synthetic biology

15:00 - 16:20 (1h20)

tRNAomics and synthetic biology

Shigeyuki Yokoyama and Eric Westhof

› Non-coding RNA-guided genome editing by CRISPR-Cas - Osamu Nureki 15:00-15:25 (25min)

› Natural non-canonical amino acids and the genetic code - Dieter Söll 15:25-15:50 (25min)

› pyRNAms enables semi-automated high-throughput nucleoside mass spectrometry data analysis for the common user - Johannes Leufken 15:50-16:05 (15min)

› RNA-seq for absolute quantification: Reprogramming the tRNA landscape during stress-induced bacterial persistence - Jennifer Hu 16:05-16:20 (15min)

Coffee break

16:20 - 16:40 (20min)

Coffee break

tRNAomics and synthetic biology

16:40 - 17:40 (1h)

tRNAomics and synthetic biology

Shigeyuki Yokoyama and Eric Westhof

› Massively Parallel Human Systems Biology in Synthetic Organisms - Jesse Rinehart 16:40-17:05 (25min)

› Characterization of changes in codons usage and tRNA expression levels during T-cells activation. - Roni Rak 17:05-17:20 (15min)

› Re-coding the Saccharomyces cerevisiae genome through codon ambiguities - Ana Rita Guimarães 17:20-17:35 (15min)

Two flash talks
tRNAomics and synthetic biology

17:35 - 17:40 (05min)

Two flash talks

Noa Aharon-Hefetz - Damien Jeandard

Functions of tRNA fragments and non canonical functions of tRNA

17:45 - 19:00 (1h15)

Functions of tRNA fragments and non canonical functions of tRNA

Anita Hopper and Magali Frugier

› Mechanisms of translation inhibition by tRNA-derived stress-induced RNAs - Pavel Ivanov 17:45-18:10 (25min)

› Elucidating the function of 3ʹtsRNAs in post transcriptional -mediated gene regulation in mammals - Mark Kay 18:10-18:35 (25min)

› The multifaceted roles of ribosome-associated tRNA-derived fragments during translation control - Norbert Polacek 18:35-18:50 (15min)

Diner

19:00 - 20:30 (1h30)

Diner

Poster session 2

20:30 - 21:30 (1h)

Poster session 2

https://trna2018.sciencesconf.org/data/program/Poster_Abstracts_tRNA_2022.pdf

Functions of tRNA fragments and non canonical functions of tRNA

9:00 - 9:55 (55min)

Functions of tRNA fragments and non canonical functions of tRNA

Anita Hopper and Magali Frugier

› Lost in translation? Transfer RNAs and graft-mobile mRNAs - Friedrich Kragler 09:00-09:25 (25min)

› Expression of tRNAs clustered nuclear genes in Arabidopsis thaliana - Guillaume Hummel 09:25-09:40 (15min)

› Enhanced tRNA gene transcription by RNA polymerase III activated in response to DNA virus infection - Nayef Jarrous 09:40-09:55 (15min)

Conference picture

9:55 - 10:10 (15min)

Conference picture

Coffee break

10:10 - 10:30 (20min)

Coffee break

Functions of tRNA fragments and non canonical functions of tRNA
Four Flash talks

10:30 - 11:30 (1h)

Functions of tRNA fragments and non canonical functions of tRNA

Anita Hopper and Magali Frugier

› Cracking the Code of Regulated Human tRNA Genes - Todd Lowe 10:30-10:55 (25min)

› Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response - Jian Lu 10:55-11:10 (15min)

11:10 - 11:25 (15min)

Four Flash talks

Cristina Cosentino - Y Gonskikh - Anna Mleczko- Mathieu Bruggeman

Lunch box
Bus

11:30 - 12:30 (1h)

Lunch box

12:20 - 13:30 (1h10)

Bus

Departure

Visit
Bus
Dopff-Moulin

14:00 - 17:00 (3h)

Visit

16:00 - 17:00 (1h)

Bus

Departure

16:30 - 17:30 (1h)

Dopff-Moulin

Visit

17:30 - 19:00 (1h30)

Visit

"Tarte flambée" diner at Dopff-Moulin Alsatian folk music

19:30 - 21:30 (2h)

"Tarte flambée" diner at Dopff-Moulin Alsatian folk music

Bus

22:00 - 22:00 ()

Bus

Departure

Amino acyl tRNA synthetases

9:00 - 10:40 (1h40)

Amino acyl tRNA synthetases

Hubert Becker and Claude Sauter

› Aminoacyl-tRNA synthetases in Charcot-Marie-Tooth disease: Mechanistic Insights and Therapeutic Opportunities - Xiang-Lei Yang 09:00-09:25 (25min)

› Glu-Pro tRNA synthetase is a constituent of a post-translational metabolon regulating adipocyte lipid metabolism - Paul Fox 09:25-09:50 (25min)

› Adaptive Partitioning of the tRNA Interaction Interface by Aminoacyl-tRNA Synthetases - David Ardell 09:50-10:05 (15min)

› Mammalian Cell Migration and Socialization is Induced by exogenous tRNA - Susan Martinis 10:05-10:20 (15min)

› Reversible inactivation of yeast mitochondrial phenylalanyl-tRNA synthetase under oxidative stress - Rajat Banerjee 10:20-10:35 (15min)

Coffee break

10:40 - 11:00 (20min)

Coffee break

Amino acyl tRNA synthetases

11:00 - 12:40 (1h40)

Amino acyl tRNA synthetases

Hubert Becker and Claude Sauter

› Making Drugs from tRNA Synthetases - Sunghoon Kim 11:00-11:25 (25min)

› Lysyl-tRNA synthetase produce second messenger Ap4A to propagates signals by polymerizing target protein - Jing Wang 11:25-11:40 (15min)

› Characterizaton of MprF-like lipid aminoacylation factors in fungi - Nathaniel Yakobov 11:40-11:55 (15min)

› A New Metalloprotein That Promotes Indirect tRNA Aminoacylation - Whitney Wood 11:55-12:10 (15min)

› Mitochondrial localized glycyl-tRNA synthetase OsGlyRS2 participates in plant response to ambient temperature - Qiang Hao 12:10-12:25 (15min)

Two Flash talks
Amino acyl tRNA synthetases

12:25 - 12:30 (05min)

Two Flash talks

Maxwell Baymiller - Marta Ferreira Amaral

Lunch

12:40 - 14:00 (1h20)

Lunch

tRNA biology and diseases

14:00 - 16:00 (2h)

tRNA biology and diseases

Marie Sissler and Ivan Tarassov

› Expression of an arginine tRNA modulates neuronal excitability - Susan Ackerman 14:00-14:25 (25min)

› Lack of Trit1-mediated tRNA isopentenylation impacts on cytoplasmic and mitochondrial translation and leads to mitochondriopathy and seizures - Ulrich Schweizer 14:25-14:50 (25min)

› Structural of the translation preinitiation complex from the pathogenic protozoa Trypanosoma cruzi - Yaser Hashem 14:50-15:05 (15min)

› tRNA methylation A Determinant of Mitochondrial Pathogenesis - Ya-Ming Hou 15:05-15:20 (15min)

› A deafness-associated mitochondrial DNA mutation perturbed the tertiary interaction and function of tRNASer(UCN) - Min-Xin Guan 15:20-15:35 (15min)

› TRMT1-catalyzed tRNA modifications ensure proper proteostasis and neurodevelopment - Dragony Fu 15:35-15:50 (15min)

Coffee break

16:00 - 16:30 (30min)

Coffee break

tRNA biology and diseases

16:30 - 17:30 (1h)

tRNA biology and diseases

Marie Sissler and Ivan Tarassov

› “Unboxing” the diversity of tRNA-mediated transcription regulation in pathogens - Constantinos Stathopoulos 16:30-16:55 (25min)

› A model for dealing with codon mismatches in host-virus interactions: Hijacking the human tRNA epitranscriptome during flavivirus infection - Cheryl Chan 16:55-17:10 (15min)

› Phosphorylated Lysyl-tRNA synthetase (LysRS) as biomarker for cancer and cardiac prognosis - Saravanan Vivekanandan 17:10-17:25 (15min)

Two Flash talks
tRNA biology and diseases

17:25 - 17:30 (05min)

Two Flash talks

Yu Nagayoshi - Ana Raquel Soares

Poster

17:30 - 18:00 (30min)

Poster

Prizes awards

Keynote lecture 3 - Elongation factor P is required to maintain proteome homeostasis at high growth rate

18:00 - 18:45 (45min)

Keynote lecture 3 - Elongation factor P is required to maintain proteome homeostasis at high growth rate

Mike Ibba

https://trna2018.sciencesconf.org/data/program/Ibba_trna2108_abstract.pdf

Closing remarks

18:45 - 19:00 (15min)

Closing remarks

Gala diner

19:30 - 22:00 (2h30)

Gala diner